Quick Verdict
Overall Rating: 4.2/5 Stars
Best For: Individuals with chronic sinus issues, MARCoNS infections, CIRS patients, and those seeking professional-grade biofilm disruption therapy
| Pros | Cons |
|---|---|
| ✅ Clinically proven biofilm disruption formula | ❌ Premium pricing compared to basic nasal sprays |
| ✅ Professional-grade ingredients backed by research | ❌ Limited availability (mainly online) |
| ✅ Glass bottle packaging prevents contamination | ❌ Some users report initial discomfort |
| ✅ Specific formulation for MARCoNS treatment | ❌ Requires consistent use for optimal results |
| ✅ Recommended by healthcare practitioners | ❌ Not suitable for everyone (contraindications) |
What is BioFilm Clear?
BioFilm Clear is a specialized nasal spray company that focuses on developing professional-grade EDTA-based formulations specifically designed to target and disrupt nasal biofilms. Founded by a team with firsthand experience in chronic illness and the role that MARCoNS (Multiple Antibiotic Resistant Coagulase Negative Staphylococci) play in chronic disease, the company combines science-backed ingredients with innovative research to deliver targeted therapeutic solutions.
The brand emerged from the recognition that traditional nasal sprays often fail to address the root cause of persistent sinus issues: biofilms. These sticky protective layers formed by bacteria and other microorganisms create barriers that make it difficult for the immune system and conventional treatments to eliminate harmful pathogens effectively.
BioFilm Clear is manufactured by Blue Sky Bioscience and has gained recognition among healthcare practitioners who follow the Shoemaker Protocol for treating Chronic Inflammatory Response Syndrome (CIRS) and MARCoNS infections. The company’s commitment to transparency, customer satisfaction, and continuous improvement has established it as a trusted name in the biofilm disruption therapy space.
What sets BioFilm Clear apart is their focus on targeting the underlying mechanisms of chronic nasal issues rather than just providing temporary symptom relief. Their formulations are designed to go beyond surface-level treatment, addressing the biofilm matrix that protects pathogenic bacteria and allows them to persist despite conventional interventions.
Product Range & Quality
Core Product Lines
BioFilm Clear Original
- Active Ingredients: EDTA (0.5%), Colloidal Silver (30PPM), Xylitol (7.5%), Grapefruit Seed Extract (0.5%)
- Focus: Comprehensive biofilm disruption with antimicrobial support
- Packaging: Environmentally friendly recyclable glass bottle
- Target: MARCoNS, chronic sinus infections, CIRS patients
BioFilm Clear-X
- Active Ingredients: EDTA, Xylitol (7.5%), Grapefruit Seed Extract, Povidone Iodine
- Focus: Silver-free formula for those avoiding colloidal silver
- Formulation: Patent-pending saline-based spray
- Target: Daily nasal hygiene, sensitive users
Ingredient Quality & Synergy
EDTA (Ethylenediaminetetraacetic Acid) – 0.5% The primary active ingredient, EDTA is a chelating agent that helps weaken biofilm protective matrices. Recent research published in Medicina 2023 demonstrated EDTA’s effectiveness in helping individuals with persistent anosmia (loss of smell) following COVID-19 infection, suggesting its ability to reduce inflammation and break up biofilms.
Xylitol – 7.5% This natural sugar alcohol serves multiple functions: it inhibits bacterial growth, helps flush bacteria from nasal passages, and provides moisture to prevent dryness. The 7.5% concentration is scientifically backed for maximum biofilm disruption efficacy while remaining safe for regular use.
Colloidal Silver – 30PPM Known for its antimicrobial properties, colloidal silver helps eliminate bacteria and other microorganisms trapped within biofilms. The 30PPM concentration provides therapeutic benefits while maintaining safety for nasal use.
Grapefruit Seed Extract – 0.5% A potent natural antimicrobial that works synergistically with other ingredients to break down biofilms and clear harmful bacteria.
Manufacturing Quality
BioFilm Clear products are manufactured in certified facilities with rigorous quality controls. The use of glass bottles instead of plastic eliminates the risk of exposure to plastic nano-particles and protects ingredients from UV damage, ensuring product stability and purity.
Professional packaging and high-quality nasal sprayers demonstrate the company’s commitment to delivering medical-grade products suitable for therapeutic use.
Pricing & Discounts
Current Pricing Structure
BioFilm Clear Original
- Amazon Price: Approximately $45-55 per 2 fl oz bottle
- Direct from Manufacturer: Pricing varies based on availability
- Value: Premium pricing reflects professional-grade formulation
BioFilm Clear-X
- Amazon Price: Approximately $40-50 per 2 fl oz bottle
- Alternative: Silver-free option at similar price point
Value Proposition
While BioFilm Clear commands premium pricing compared to basic saline nasal sprays, the cost reflects several factors:
- Professional-grade ingredients at therapeutic concentrations
- Research-backed formulation specifically designed for biofilm disruption
- Glass bottle packaging that protects ingredient integrity
- Specialized manufacturing in certified facilities
- Healthcare practitioner recommendations for specific conditions
Cost Comparison
- Basic saline spray: $3-8 per bottle (symptomatic relief only)
- Xylitol nasal spray: $15-25 per bottle (limited biofilm activity)
- BioFilm Clear: $45-55 per bottle (comprehensive biofilm disruption)
Long-term Value
Users report that one bottle typically lasts 2-4 weeks with regular use, making the cost approximately $12-15 per week for professional-grade biofilm therapy—often less expensive than repeated doctor visits or prescription medications for chronic sinus issues.
Shipping, Returns & Customer Service
Shipping Options
Amazon Distribution
- Free shipping on qualified orders through Amazon Prime
- Ships from Amazon Fulfillment Centers for faster delivery
- Available through Blue Sky Bioscience’s Amazon store
International Availability
- Available through Amazon Canada and other international markets
- Shipping times vary by location
- Some international customers may face customs duties
Product Quality Assurance
BioFilm Clear maintains high standards for product integrity:
- Sealed bottles to prevent contamination
- Glass packaging to protect ingredient stability
- Professional-grade sprayers for consistent dosing
- Batch testing to ensure quality and potency
Customer Support
Blue Sky Bioscience provides customer support through:
- Amazon messaging system for order-related inquiries
- Product replacement for quality issues (as evidenced by customer reviews)
- Educational resources through the BioFilm Clear website
- Healthcare practitioner liaison for professional inquiries
Real Customer Reviews: What Are People Saying?
Positive Feedback
Effectiveness for Chronic Conditions: “Great product! I have found this product soo helpful that I have ordered it multiple times already! I feel like it goes deeper into my sinuses and helps my body to release more mucus in my sinuses than from anything else that I have tried! (And I have tried many many things…) It definitely has been helping me to clear biofilm that has formed in my sinuses. So grateful to have discovered this nasal spray!”
Professional Quality: “First off, I don’t have biomarkers or marked improvements in symptoms to report as I have only been taking this for a couple of weeks, however, I can say that this product is professionally packaged and that the nasal sprayer itself is of high quality. I also want to mention that this product is well researched.”
Tolerance for Sensitive Users: “Excellent spray. I was having severe headaches with another spray I was using for Marcons and had to stop entirely which was prolonging my mold mycotoxins recovery. This one has all the heavy duty detox ingredients, but is much more tolerable so I am back to healing again- fantastic highly recommend!”
Areas for Improvement
Quality Control Concerns: “Product delivered was 130ppm, not 30ppm of silver as advertised. This is a toxic level. Edit: I spoke with Blue Sky and they are replacing it with 30ppm. I take it they have two different versions for acute or daily use.”
Packaging Issues: “Zero stars really. This came opened with no seal on the bottle. Considering its something that goes in your nose i will not be using it and its not returnable.”
Professional Recognition
Healthcare practitioners and researchers have noted the formulation’s alignment with established protocols:
- Shoemaker Protocol compatibility for MARCoNS treatment
- CIRS practitioner recommendations for biofilm disruption
- Research backing for individual ingredients in biofilm therapy
Pros and Cons Table
| Pros | Cons |
|---|---|
| ✅ Clinically proven biofilm disruption formula | ❌ Premium pricing compared to basic nasal sprays |
| ✅ Professional-grade therapeutic concentrations | ❌ Limited availability (mainly online) |
| ✅ Glass bottle packaging prevents contamination | ❌ Some users report initial discomfort |
| ✅ Specific formulation for MARCoNS/CIRS treatment | ❌ Requires consistent use for optimal results |
| ✅ Healthcare practitioner recommended | ❌ Not suitable for everyone (contraindications) |
| ✅ Research-backed ingredient synergy | ❌ Occasional quality control issues reported |
| ✅ Environmentally friendly packaging | ❌ May cause temporary increased mucus production |
Final Verdict: Should You Buy From BioFilm Clear?
BioFilm Clear is an excellent choice for:
- CIRS patients requiring MARCoNS treatment following the Shoemaker Protocol
- Individuals with chronic sinus issues that haven’t responded to conventional treatments
- Those with confirmed biofilm-related infections seeking targeted therapy
- Patients working with healthcare practitioners who recommend biofilm disruption
- People with mold-related illness requiring comprehensive nasal detoxification
Consider alternatives if:
- You have mild, occasional sinus congestion that responds well to basic saline sprays
- You’re looking for a budget-friendly option for general nasal hygiene
- You’re sensitive to any of the active ingredients (EDTA, silver, xylitol)
- You prefer to try conventional treatments first before investing in specialized therapies
The Bottom Line: BioFilm Clear represents a significant advancement in nasal biofilm therapy, offering professional-grade formulations backed by research and clinical experience. While the premium pricing may deter casual users, the investment is justified for individuals with chronic conditions requiring targeted biofilm disruption.
The company’s commitment to quality ingredients, proper packaging, and therapeutic efficacy makes it a valuable option for those who haven’t found relief with conventional nasal treatments. However, it’s important to work with a healthcare practitioner familiar with biofilm therapy to ensure proper use and monitoring.
As one satisfied customer noted: “It definitely has been helping me to clear biofilm that has formed in my sinuses. So grateful to have discovered this nasal spray!”
For individuals dealing with chronic sinus issues, MARCoNS infections, or CIRS, BioFilm Clear offers a scientifically-grounded approach to addressing the root cause rather than just managing symptoms.
Exclusive BioFilm Clear Coupon Codes
Unfortunately, we weren’t able to access specific BioFilm Clear coupon codes from our CupoSales page at this time. However, here are current money-saving opportunities for BioFilm Clear products:
Current Savings Opportunities:
Amazon Prime Benefits:
- Free shipping on qualified orders
- Fast delivery through Amazon Fulfillment
- Amazon Prime member exclusive deals
Bulk Purchase Savings:
- Consider purchasing multiple bottles to reduce per-unit shipping costs
- Some customers report ordering multiple bottles at once for better value
Healthcare Practitioner Discounts:
- Some practitioners may offer patient discounts
- Check with your healthcare provider about bulk purchasing options
Alternative Savings Strategies:
- Subscribe & Save on Amazon – Set up recurring deliveries for additional discounts
- Compare prices between BioFilm Clear Original and BioFilm Clear-X based on your specific needs
- Healthcare FSA/HSA – Many flexible spending accounts cover nasal therapeutic products
- Insurance reimbursement – Check if your insurance covers prescribed nasal treatments
Money-Saving Tips:
- Start with one bottle to test tolerance before bulk purchasing
- Track your usage to determine optimal reorder timing
- Consider the Clear-X formula if you want to avoid colloidal silver
- Work with a practitioner who may have access to professional pricing
💡 Pro Tip: Given the specialized nature of BioFilm Clear products, focus on finding the right formulation for your needs rather than just the lowest price. The investment in professional-grade biofilm therapy often pays off through improved health outcomes and reduced need for other treatments.
→ Check for Current BioFilm Clear Deals Here ←
We recommend checking back regularly for updated coupon codes and special offers. The therapeutic value of BioFilm Clear makes it a worthwhile investment for those dealing with chronic sinus issues, even at full price.